The Correct Answer is D!

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A patient without any risk factors for increased bleeding is undergoing a procedure with low bleeding risk. He is taking apixaban 5 mg twice daily, and has creatinine clearance of 60 mL/min.

The patient should:

  1. Discontinue the apixaban 12 hours before the procedure, no need for bridging
  2. Discontinue the apixaban 72 hours before the procedure and bridge with a low molecular weight heparin until 12 hours before the procedure
  3. Continue uninterrupted apixaban through the procedure
  4. Discontinue the apixaban 24 hours before the procedure and do not bridge before the procedure

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