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Question:

Which of the following statements represents a clinical manifestation of infective endocarditis?

  1. Congestive heart failure, now the leading cause of death in infective endocarditis
  2. Clubbing, seen in early disease and observed in up to 50% of cases
  3. Fever, observed in up to 75% of cases
  4. Osler's nodes on the pads of the fingers and toes

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