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A 48 year-old woman has the diagnosis of HCM with a dynamic LVO obstruction and will be undergoing myectomy for symptoms. There is no FH of HCM or sudden death, but she has three daughters who are active and in excellent health. She had genetic testing done which showed a pathogenic mutation in the beta myosin heavy chain, which is a sequence variant known to cause HCM.

Which of the following is appropriate for this patient and her family?

  1. A daughter who does not have the mother's mutation on gene testing does not need further follow-up
  2. A daughter who has had a normal echo at age 25 does not need further follow-up with either repeat echo or genetic testing
  3. The mother's mutation indicates that she is at high risk for sudden death
  4. The grandchildren of the affected patient should undergo periodic echocardiography yearly as teenagers even if the daughter of the grandchildren has a normal echocardiogram

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1. Source: "Comparative Analysis of Pre/Post Assessments of Live/Didactic Course Attendees when compared to Mico-Learning/Online Course Users., "Knowledge to Practice, 2017.