The Correct Answer is B!

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A 40-year-old woman with no past medical history presents to clinic with 4 weeks of increased weakness and fatigue. She has also noted increased abdominal fullness and easy bruising lately. The remainder of the review of systems is negative. She takes no medications and denies tobacco or alcohol use. There is no significant family history. On physical exam, vital signs are within normal limits. A few ecchymosis are noted on the upper and lower extremities. Abdominal exam reveals a palpable spleen 4 cm below the left costal margin. Laboratory studies reveal leukocyte count 55,000/uL, platelets 510,000/uL. A peripheral blood smear reveals numerous bands and myelocytes. A bone marrow specimen shows >60% t(9,22) positive cells by fluorescence in situ hybridization.

Which of the following is the most appropriate treatment?

  1. Interferon and low-dose cytarabine
  2. Imatinib
  3. Interferon and imatinib
  4. Allogenic bone marrow transplant

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1.  Source: "Comparative Analysis of Pre/Post Assessments of Live/Didactic Course Attendees when compared to Mico-Learning/Online Course Users., "Knowledge to Practice, 2017.